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Validation of
Ingredients
Holistic Recommendations
References
WHO MAY BENEFIT (LIFESTYLE)
Men
and Women over 40 years of age.
Individuals
with low DHEA blood serum levels.
Women
following menopause and/or hysterectomy.
Men
exhibiting a family history of cardiovascular disease.
Individuals
whose diet is high in refined carbohydrates.
Individuals
desiring to boost their immune system.
Women
on oral and vaginal contraceptives.
DOSAGE & DIRECTIONS
Men 40 to 55: Take one 25 mg tablet daily with food on a consistent basis.
Men over 55: Take two 25 mg tablets daily with food on a consistent basis.
Women over 40 or on contraceptives: Take one 25 mg tablet daily with food on a consistent
basis.
Patients with low DHEA: Take two to three 25 mg tablets daily until normal DHEA level has been
achieved; then reduce dosage to one tablet or follow age guidelines above.
Women in post menopause or surgical menopause: Take two
tablets daily with food on a
consistent basis.
Important
Note: DHEA does not have a "feedback"
mechanism so supplemen-tation will not curb the body's production of
this hormone. Although DHEA is a promising precursor
hormone, neither science nor medicine has a full
understanding of this steroid and how it metabolizes into estrogens, androgens, and other
hormones. Therefore, the above recommended dosages should not
be exceeded.
CONTRAINDICATIONS & PRECAUTIONS
In women, high dosage levels of DHEA can result in hirsutism (excess body hair), fatigue,
anger, depression, and acne rash. High dosage levels for prolonged periods may stimulate
breast cysts or uterine fibroids.
In men, high dosage levels of DHEA may contribute to prostatic hypertrophy, low energy,
and aggressive anger.
The dosage levels recommended in this report are within safety tolerances and
guidelines for normal DHEA usage. Never take supplements at the same time as medications.
If both must be taken with food, take them at different meals.
The following substances have been determined to lower DHEA levels: corticosteroids,
progesterone and other oral contraceptives, cimetidine (Tagamet), lovastatin (Mevacor),
ketoconazole (Nizoral), anticonvulsants, carbamazepine, phenobarbitals, and alcohol.
FACTOR FOUR FORMULATION
DHEA-Forte is manufactured from the steroidal saponin diogenin and converted by a series
of eight chemical reactions into pure dehydroepiandrosterone.
When a DHEA tablet is swallowed, it is absorbed from the intestinal
tract into the portal vein where it is transported into the liver.
Most of the DHEA is metabolized by the liver before circulating
throughout the bloodstream to the rest of the body.1
When DHEA is metabolized, a chemical called sulfate is added which
consists of the mineral sulfur combined with oxygen, creating DHEAS
- short for DHEA-sulfate. About 90% of this steroid hormone is in
the DHEAS form with the balance circulating as DHEA 2
It is important to note that DHEA is lipophilic (soluble in fat)
while DHEAS is water soluble. DHEA can cross the blood-brain barrier
and influence the brain whereas DHEAS cannot.3
Some manufacturers "micronize" DHEA, a process that creates smaller
particles that can be absorbed from the intestines into the
lymphatic system and partially bypass the liver, thus increasing the
amount of "free" DHEA in the blood. Such micronization has been
touted as enhancing the bioavailability of DHEA although there is
very limited data supporting this claim.4
Titan Laboratories does not micronize its DHEA because (1) limited data exists regarding
the impact of DHEA on the brain.5 Titan is therefore reluctant to alter or
"shortcut" the natural pathway of DHEA as it is produced by the adrenals.
(2) DHEAS is consistently stable on a daily basis while free DHEA cycles throughout the
day and may increase up to a hundredfold at a given moment or drop drastically under
stress.6 Again, Titan is reluctant to alter the naturally occurring 90/10
percentage relationship of DHEAS to free DHEA pending further clinical studies.
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